A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress

Meng Yu; Stephen L Ambrose; Zachary L Whaley; Sanjun Fan; John D Gorden; Ronald J Beyers; Dean D Schwartz; Christian R Goldsmith

doi:10.1021/ja507034d

A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress

J Am Chem Soc. 2014 Sep 17;136(37):12836-9. doi: 10.1021/ja507034d. Epub 2014 Sep 4.

Authors

Meng Yu¹, Stephen L Ambrose, Zachary L Whaley, Sanjun Fan, John D Gorden, Ronald J Beyers, Dean D Schwartz, Christian R Goldsmith

Affiliation

¹ Department of Chemistry and Biochemistry, ‡Magnetic Resonance Imaging Research Center, and §Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University , Auburn, Alabama 36849, United States.

PMID: 25187295
DOI: 10.1021/ja507034d

Abstract

A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Antioxidants / chemistry*
Antioxidants / pharmacology
Cell Line
Contrast Media / chemistry*
Contrast Media / pharmacology
Coordination Complexes / chemistry*
Coordination Complexes / pharmacology
Hydrogen Peroxide / analysis*
Magnetic Resonance Imaging
Manganese / chemistry*
Manganese / pharmacology
Mice
Models, Molecular
Oxidation-Reduction
Oxidative Stress / drug effects*
Rats

Substances

Antioxidants
Contrast Media
Coordination Complexes
Manganese
Hydrogen Peroxide