Random yet deterministic: convergent immunoglobulin responses to influenza

Andrew J Martins; John S Tsang

doi:10.1016/j.tim.2014.07.005

Random yet deterministic: convergent immunoglobulin responses to influenza

Trends Microbiol. 2014 Sep;22(9):488-9. doi: 10.1016/j.tim.2014.07.005.

Authors

Andrew J Martins¹, John S Tsang²

Affiliations

¹ Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
² Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Trans-NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD, USA. Electronic address: john.tsang@nih.gov.

Abstract

B cell clonal expansion is a hallmark of host-defense and vaccination responses. Given the vast immunoglobulin repertoire, individuals may expand B cells carrying largely distinct immunoglobulin genes following antigenic challenge. Using immunoglobulin-repertoire sequencing to dynamically track responses to influenza vaccination, Jackson et al. find evidence of convergent immunoglobulin responses across individuals.

Published by Elsevier Ltd.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antibodies, Viral / genetics*
Antibodies, Viral / immunology*
Gene Rearrangement, B-Lymphocyte*
Humans
Influenza Vaccines / immunology*
Influenza, Human / prevention & control*

Substances

Antibodies, Viral
Influenza Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding