Cell Biol Int Rep. 1989 Dec;13(12):1007-21.

Synapsin I, a neuron-specific phosphoprotein interacting with small synaptic vesicles and F-actin.

Benfenati F, Valtorta F, Bähler M, Greengard P.

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Institute of Human Physiology, University of Modena, Italy.

Abstract

Synapsin I is a neuron-specific phosphoprotein which is a substrate for cAMP- and Ca2+/calmodulin-dependent protein kinases. It is specifically localized to the cytoplasmic side of small synaptic vesicles. The interaction of synapsin I with the synaptic vesicle membrane is complex in nature, since it is modulated by phosphorylation and involves binding of different domains of the molecule to phospholipid and protein components of synaptic vesicles. Synapsin I is also able to interact with actin filaments in a phosphorylation-dependent manner. Because of these properties, it has been hypothesized that synapsin I acts as a dynamic link between synaptic vesicles an the actin meshwork of the nerve terminal, thereby modulating the release of neurotransmitter.

PMID:: 2517594; [PubMed - indexed for MEDLINE]

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Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for regulation of neurotransmitter release. [Proc Natl Acad Sci U S A. 1991]
Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for regulation of neurotransmitter release.
Benfenati F, Valtorta F, Greengard P. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):575-9.
Synapsin I bundles F-actin in a phosphorylation-dependent manner. [Nature. 1987]
Synapsin I bundles F-actin in a phosphorylation-dependent manner.
Bähler M, Greengard P. Nature. 1987 Apr 16-22; 326(6114):704-7.
Interactions of synapsin I with small synaptic vesicles: distinct sites in synapsin I bind to vesicle phospholipids and vesicle proteins. [J Cell Biol. 1989]
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Benfenati F, Bähler M, Jahn R, Greengard P. J Cell Biol. 1989 May; 108(5):1863-72.
Review The synapsins and the regulation of synaptic function. [Bioessays. 1990]
Review The synapsins and the regulation of synaptic function.
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Valtorta F, Tarelli FT, Campanati L, Villa A, Greengard P. Cell Biol Int Rep. 1989 Dec; 13(12):1023-38.

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Cited by 3 PubMed Central articles

Review Signaling for vesicle mobilization and synaptic plasticity. [Mol Neurobiol. 2008]
Review Signaling for vesicle mobilization and synaptic plasticity.
Levitan ES. Mol Neurobiol. 2008 Feb; 37(1):39-43. Epub 2008 Apr 30.
Review Synaptic proteins as multi-sensor devices of neurotransmission. [BMC Neurosci. 2006]
Review Synaptic proteins as multi-sensor devices of neurotransmission.
Brachya G, Yanay C, Linial M. BMC Neurosci. 2006 Oct 30; 7 Suppl 1:S4. Epub 2006 Oct 30.
Colocalization of synapsin and actin during synaptic vesicle recycling. [J Cell Biol. 2003]
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Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P, Shupliakov O. J Cell Biol. 2003 May 26; 161(4):737-47. Epub 2003 May 19.

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