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Gut Liver. 2015 Jan;9(1):87-93. doi: 10.5009/gnl13345.

Effect of short-term partial enteral nutrition on the treatment of younger patients with severe Crohn's disease.

Author information

  • 1Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea.

Abstract

BACKGROUND/AIMS:

To analyze the effect of short-term supportive temporary partial enteral nutrition therapy for treating severe pediatric Crohn's disease (CD).

METHODS:

We conducted a prospective, open-label study in pediatric patients with CD (n=78) from January 2007 to December 2011. The CD patients were divided into three groups according to disease severity (mild, moderate, and severe). Seventeen patients with severe CD received short-term partial enteral nutrition (SPEN) in addition to their general diet for 4 weeks after the induction of remission with medical treatment. This SPEN group was further divided into two groups by age (<13 years, ≥13 years). Nutritional parameters and Pediatric Crohn's Disease Activity Index scores were analyzed at the initial enrollment and following 1 year of treatment for all groups.

RESULTS:

Nutritional status improved substantially after 1 year of treatment in the severe CD group. Nutritional status in the SPEN group improved considerably more than that in the non-SPEN group. Additionally, the <13-year-old group demonstrated better nutritional status improvement than the ≥13-year-old group.

CONCLUSIONS:

SPEN may be effective in pediatric patients with severe CD for improving nutritional status and moderating disease severity.

KEYWORDS:

Crohn disease; Disease activity; Nutritional status; Partial enteral nutrition; Younger age

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