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Neuron. 1989 Apr;2(4):1313-23.

Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction.

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  • 1Howard Hughes Medical Institute, University of California, Berkeley 94720.

Abstract

Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that trp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells.

PMID:
2516726
[PubMed - indexed for MEDLINE]
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