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Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1323-9. doi: 10.1016/j.numecd.2014.07.003. Epub 2014 Jul 22.

Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations.

Author information

  • 1Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
  • 2Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
  • 3Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
  • 4Department of Epidemiology and Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
  • 5Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
  • 6Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
  • 7Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain. Electronic address: jose.ordovas@tufts.edu.

Abstract

BACKGROUND AND AIMS:

Lipoprotein lipase (LPL) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown.

METHODS AND RESULTS:

We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45-75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) (P = 0.002) and waist circumference (WC) (P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) (P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study (n = 1334).

CONCLUSION:

Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.

Copyright © 2014. Published by Elsevier B.V.

KEYWORDS:

Gene-diet interaction; Lipoprotein lipase; Obesity; Polyunsaturated fatty acids

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