The primordial thymus: everything you need under one roof

Graham Anderson; Song Baik

doi:10.1016/j.immuni.2014.07.012

The primordial thymus: everything you need under one roof

Immunity. 2014 Aug 21;41(2):178-80. doi: 10.1016/j.immuni.2014.07.012.

Authors

Graham Anderson¹, Song Baik²

Affiliations

¹ School of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: g.anderson@bham.ac.uk.
² School of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK.

PMID: 25148021
DOI: 10.1016/j.immuni.2014.07.012

Abstract

Lymphocytes normally develop within anatomically distinct tissues. In Cell Reports, Swann et al. (2014) reconstruct the primordial thymus and suggest that it was a site of combined T and B lymphopoiesis before evolving into an organ specialized for T cell production.

Publication types

Comment

MeSH terms

Animals
Eye Proteins / genetics*
Forkhead Transcription Factors / genetics*
Thymus Gland / metabolism*

Substances

Eye Proteins
Forkhead Transcription Factors

Grants and funding

G1000213/MRC_/Medical Research Council/United Kingdom