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PLoS One. 2014 Aug 21;9(8):e105516. doi: 10.1371/journal.pone.0105516. eCollection 2014.

Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals.

Author information

  • 1Department of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China; Department of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
  • 2The Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
  • 3Department of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
  • 4First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China.
  • 5First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; The Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.

Abstract

BACKGROUND:

Contribution of cardiovascular disease related genetic risk factors for stroke are not clearly defined. We performed a genetic association study to assess the association of 56 previously characterized gene variants in 34 candidate genes from cardiovascular disease related biological pathways with ischemic stroke and cerebral hemorrhage in a Chinese population.

METHODS:

There were 1280 stroke patients (1101 with ischemic stroke and 179 with cerebral hemorrhage) and 1380 controls in the study. The genotypes for 56 polymorphisms of 34 candidate genes were determined by the immobilized probe approach and the associations of gene polymorphisms with ischemic stroke and cerebral hemorrhage were performed by logistic regression under an allelic model.

RESULTS:

After adjusting for age, sex, BMI and hypertension status by logistic regression analysis, we found that NPPA rs5063 was significantly associated with both ischemic stroke (odds ratio [OR] 0.69; 95% confidence interval [CI], 0.52 to 0.90; P = 0.006) and cerebral hemorrhage(OR = 0.39; 95%CI, 0.19 to 0.78; P = 0.007). In addition, MTHFR rs1801133 also was associated with cerebral hemorrhage (OR = 1.48; 95%CI, 1.16 to 1.89; P = 0.001) but not with ischemic stroke (OR = 1.08; 95%CI, 0.96 to 1.22; P = 0.210). After false discovery rate (FDR) correction, the association of NPPA rs5063 and MTHFR rs1801133 with cerebral hemorrhage remained significant.

CONCLUSIONS:

The NPPA rs5063 is associated with reduced risk for cerebral hemorrhage and MTHFR rs1801133 is associated with increased risk of cerebral hemorrhage in a Chinese population.

PMID:
25144711
[PubMed - indexed for MEDLINE]
PMCID:
PMC4140791
Free PMC Article
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