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J Sci Food Agric. 2014 Aug 21. doi: 10.1002/jsfa.6881. [Epub ahead of print]

6,6'-bieckol inhibits adipocyte differentiation through down-regulation of adipogenesis and lipogenesis in 3T3-L1 cells.

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  • 1Gyeongbuk Institute for Marine Bio-Industry, Uljin, 767-813, Republic of Korea; Food Science and Biotechnology Major, Andong National University, Andong, 760-749, Republic of Korea.



Brown alga, have been used for their nutritional value as well as a source of bioactive compounds with antioxidant, anti-inflammatory, antimicrobial, and anti-obesity effects. Obesity is an important condition implicated in various diseases, including diabetes, hypertension, dyslipidemia, and coronary heart disease. However, anti-obesity effects of the Eisenia bicyclis remain unknown.


we investigated the anti-obesity effects of the 6,6'-bieckol, 6,8'-bieckol, 8,8'-bieckol, dieckol, and phlorofucofuroeckol-A that were isolated from E. bicyclis. The anti-obesity activity was evaluated by examining the inhibition of differentiation of 3T3-L1 adipocytes and the expression of peroxisome proliferator-activated receptor γ (PPARγ), CCATT/enhancer-binding protein α (C/EBPα), and sterol regulatory element binding protein-1c (SREBP-1c) in the mRNA and protein level. Differentiated 3T3-L1 cells were treated with the purified phlorotannins at concentrations of 10, 25, and 50 µg mL-1 for 8 d. The results indicated that, the purified phlorotannins suppressed the differentiation of 3T3-L1 adipocytes in a dose-dependent manner, without toxic effects. Among the five compounds, 6,6'-bieckol markedly decreased lipid accumulation and expression levels of PPARγ, C/EBPα, SREBP-1c (mRNA and protein), and fatty acid synthase and acyl-coA carboxylase (mRNA).


These findings suggest that E. bicyclis suppressed differentiation of 3T3-L1 adipocyte through down-regulation of adipogenesis and lipogenesis.

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3T3-L1; adipogenesis; anti-obesity; lipogenesis; phlorotannins

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