Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1989 Dec 14;342(6251):749-57.

A regulatory hierarchy for cell specialization in yeast.

Author information

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco 94143.


The specialized sets of genes that determine different cell types in yeast are controlled by combinations of DNA-binding proteins some of which are present only in certain cell types whereas others are present in all cell types. Final differentiation requires an inductive signal that triggers both gene transcription and cell-cycle arrest. Synthesis of the proteins coded by the 'master regulatory' mating-type locus is regulated so as to generate a heterogeneous mitotic cell population containing a stem-cell lineage.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk