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Nature. 1989 Dec 14;342(6251):749-57.

A regulatory hierarchy for cell specialization in yeast.

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  • 1Department of Biochemistry and Biophysics, University of California, San Francisco 94143.

Abstract

The specialized sets of genes that determine different cell types in yeast are controlled by combinations of DNA-binding proteins some of which are present only in certain cell types whereas others are present in all cell types. Final differentiation requires an inductive signal that triggers both gene transcription and cell-cycle arrest. Synthesis of the proteins coded by the 'master regulatory' mating-type locus is regulated so as to generate a heterogeneous mitotic cell population containing a stem-cell lineage.

PMID:
2513489
[PubMed - indexed for MEDLINE]
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