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Neurobiol Aging. 2015 Jan;36(1):434-45. doi: 10.1016/j.neurobiolaging.2014.07.009. Epub 2014 Jul 15.

Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies.

Author information

  • 1Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy. Electronic address: l.bonanni@unich.it.
  • 2Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy.
  • 3Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
  • 4Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Institute for Advanced Biomedical Technologies (ITAB), G. d'Annunzio University Foundation, Chieti, Italy.
  • 5Center for Memory Disturbances and Alzheimer's Center, Section of Neurology, University of Perugia, Perugia, Italy.

Abstract

Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominant frequency <8 Hz and dominant frequency variability >1.5 Hz, typical of early DLB, are already present at the stage of MCI and to evaluate whether EEG abnormalities can predict the development of DLB. Forty-seven MCI subjects were followed for 3 years. EEG recordings were obtained at admission and at the end of the study. At the end of follow-up, 20 subjects had developed probable DLB (MCI-DLB), 14 had probable AD (MCI-AD), 8 did not convert to dementia, 5 developed a non-AD/DLB dementia. One hundred percent of MCI-DLB showed EEG abnormalities at admission. Ninety three percent of MCI-AD maintained a normal EEG throughout the study. QEEG may represent a powerful tool to predict the progression from MCI to DLB with a sensitivity and specificity close to 100%.

Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Dementia with Lewy bodies; Mild cognitive impairment; Quantitative EEG

PMID:
25129239
[PubMed - indexed for MEDLINE]
PMCID:
PMC4270449
Free PMC Article
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