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Eur J Clin Microbiol Infect Dis. 1989 Oct;8(10):897-900.

Influenza subtype-specific immunoglobulin A and G responses after booster versus one double-dose vaccination in hemodialysis patients.

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  • 1Abteilung für Medizinische Mikrobiologie, Christian-Albrechts-Universität, Kiel, FRG.


The antibody response in hemodialysis patients was studied after one double dose of influenza vaccine versus one conventional dose plus a booster dose five weeks later. The influenza virus subtype specific IgA and IgG responses were recorded by means of an indirect immunofluorescence assay over a period of 20 weeks. Higher antibody titers, higher response rates and a higher rate of development of protective titers after the single double-dose vaccine indicated it was superior to the single dose/booster dose regimen. It is therefore suggested that hemodialysis patients are immunized with a higher dosage of influenza vaccine to achieve better protection rates.

[PubMed - indexed for MEDLINE]
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