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J Korean Med Sci. 2014 Aug;29(8):1108-12. doi: 10.3346/jkms.2014.29.8.1108. Epub 2014 Jul 30.

Comparison of Korean COPD guideline and GOLD initiative report in term of acute exacerbation: a validation study for Korean COPD guideline.

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  • 1Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Korea.
  • 2Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 3Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 4Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
  • 5Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
  • 6Department of Internal Medicine, Yeouido St. Marry's Hosital, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 7Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 8Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
  • 9Department of Internal Medicine,Yeungnam University College of Medicine, Daegu, Korea.
  • 10Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.


The purpose of this study was to compare the Korean COPD guideline to GOLD consensus report in terms of acute exacerbation. A total of 361 patients were enrolled in this study, and 16.9% of them experienced acute exacerbation during the follow-up. A total of 6.3% of patients in GOLD A, 9.5% in GOLD B, 7.7% in GOLD C and 17.0% of GOLD D experienced exacerbation during the first year of follow-up, respectively (P=0.09). There was no one who experienced exacerbation during the first year of follow-up in the Korean group 'ga'. The 12-month exacerbation rates of Korean group 'na' and 'da' were 4.5% and 16.0%, respectively (P<0.001). We explore the experience of exacerbation in patients with change of their risk group after applying Korean COPD guideline. A total of 16.0% of the patients who were reclassified from GOLD A to Korean group 'da' experienced acute exacerbation,and 15.3% from GOLD B to Korean group 'da' experienced acute exacerbation. In summary, the Korean COPD guideline is useful to differentiate the high risk from low risk for exacerbation in terms of spirometry. This indicates that application of Korean COPD guideline is appropriate to treat Korean COPD patients.


Assessment; COPD; Exacerbation; FEV1; Guidelines

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