Format

Send to:

Choose Destination
See comment in PubMed Commons below
N Z Vet J. 2015 Mar;63(2):117-20. doi: 10.1080/00480169.2014.955068. Epub 2015 Jan 19.

Post-vaccinal distemper encephalitis in two Border Collie cross littermates.

Author information

  • 1a Gribbles Veterinary Pathology , PO Box 3866, Christchurch , New Zealand.

Abstract

CASE HISTORY:

One 4.5-month-old male Border Collie cross presented with aggression and seizures in October 2006. A 16-month-old, female, spayed Border Collie cross presented with hypersalivation and a dropped jaw and rapidly became stuporous in September 2007. The dogs were littermates and developed acute neurological signs 5 and 27 days, respectively, after vaccination with different modified live vaccines containing canine distemper virus.

HISTOPATHOLOGICAL FINDINGS:

Sections of brain in both dogs showed evidence of encephalitis mainly centred on the grey matter of brainstem nuclei, where there was extensive and intense parenchymal and perivascular infiltration of histiocytes and lymphocytes. Intra-nuclear and intra-cytoplasmic inclusions typical of distemper were plentiful and there was abundant labelling for canine distemper virus using immunohistochemistry.

DIAGNOSIS:

Post-vaccinal canine distemper.

CLINCIAL RELEVANCE:

Post-vaccinal canine distemper has mainly been attributed to virulent vaccine virus, but it may also occur in dogs whose immunologic nature makes them susceptible to disease induced by a modified-live vaccine virus that is safe and protective for most dogs.

KEYWORDS:

Dog; IHC; canine distemper; encephalitis; vaccine

PMID:
25120026
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk