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Sci Rep. 2014 Aug 13;4:6044. doi: 10.1038/srep06044.

Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy.

Author information

  • 11] Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [2] [3].
  • 21] Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [2] Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, 980-8575, JAPAN [3].
  • 31] Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [2] Department of Clinical Pathophysiology, Tokyo Dental College, Chiba-shi, Chiba, 261-8502, JAPAN.
  • 4Department of Oral Pathology, Showa University School of Dentistry, Shinagawa-ku, Tokyo, 145-8515, JAPAN.
  • 5Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN.
  • 61] Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [2] Organ Technologies Inc., Tokyo, 108-0074, JAPAN.
  • 7Section of Oral Implantology and Regenerative Dental Medicine, Graduate School of Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, JAPAN.
  • 8Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, 980-8575, JAPAN.
  • 9Department of Clinical Pathophysiology, Tokyo Dental College, Chiba-shi, Chiba, 261-8502, JAPAN.
  • 10Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8525, JAPAN.
  • 11Section of Oral Pathology, Department of Oral Restitution, Graduate School of Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, JAPAN.
  • 121] Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [2] Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, JAPAN [3] Organ Technologies Inc., Tokyo, 108-0074, JAPAN [4].

Abstract

Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.

PMID:
25116435
[PubMed - indexed for MEDLINE]
PMCID:
PMC4131220
Free PMC Article
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