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Vaccine. 2014 Sep 15;32(41):5259-65. doi: 10.1016/j.vaccine.2014.07.069. Epub 2014 Aug 8.

Global vaccine supply. The increasing role of manufacturers from middle income countries.

Author information

  • 1Global Solutions for Infectious Diseases, South San Francisco, CA, USA. Electronic address:
  • 2Vaccine Consultant, Beijing, PR China; Former WHO Medical Officer, EPI, Democratic People's Republic of Korea.
  • 3Division of Clinical Trials and Pharmacovigilance, Instituto Butantan, Sao Paulo, Brazil.


Hallmarks in the remarkable evolution of vaccines and their application include the eradication of smallpox, the development and delivery of the early childhood vaccines and the emergence of recombinant vaccines initiated by the hepatitis B vaccine. Now we enter a most exciting era as vaccines are increasingly produced and delivered in less developed countries. The results are dramatic decreases in childhood morbidity and mortality around the world.

Copyright © 2014 Elsevier Ltd. All rights reserved.


Less develop countries; Production; Supply; Vaccine

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