Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychol. 2014 Dec;103:19-23. doi: 10.1016/j.biopsycho.2014.07.017. Epub 2014 Aug 4.

Preliminary findings on the heritability of the neural correlates of response inhibition.

Author information

  • 1MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom.
  • 2Institute for Clinical Radiology, University of Munich, Munich, Germany.
  • 3Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
  • 4Department of Psychiatry, University of Halle, Halle, Germany.
  • 5Department of Psychology, University of Bonn, Bonn, Germany. Electronic address:


Imaging genetics examines genetic influences on brain structure and function. This preliminary study tested a fundamental assumption of that approach by estimating the heritability of the blood oxygen level dependent (BOLD) signal during antisaccades, a measure of response inhibition impaired in different psychiatric conditions. One hundred thirty-two healthy same-sex reared-together twins (90 monozygotic (MZ; 32 male) and 42 dizygotic (DZ; 24 male)) performed antisaccades in the laboratory. Of these, 96 twins (60 MZ, 28 male; 36 DZ, 22 male) subsequently underwent functional magnetic resonance imaging (fMRI) during antisaccades. Variation in antisaccade direction errors in the laboratory showed significant heritability (47%; 95% confidence interval (CI) 22-65). In fMRI, the contrast of antisaccades with prosaccades yielded BOLD signal in fronto-parietal-subcortical networks. Twin modelling provided tentative evidence of significant heritability (50%, 95% CI: 18-72) of BOLD in the left thalamus only. However, due to the limited power to detect heritability in this study, replications in larger samples are needed.

Copyright © 2014 Elsevier B.V. All rights reserved.


Behavioural genetics; Cognitive control; Eye movements; Response inhibition; fMRI

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk