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Nat Med. 2014 Aug;20(8):833-46. doi: 10.1038/nm.3647.

Hematopoietic stem cell niche maintenance during homeostasis and regeneration.

Author information

  • 11] Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA. [2] The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Bronx, New York, USA.
  • 21] Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA. [2] The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Bronx, New York, USA. [3] Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

Abstract

The bone marrow niche has mystified scientists for many years, leading to widespread investigation to shed light into its molecular and cellular composition. Considerable efforts have been devoted toward uncovering the regulatory mechanisms of hematopoietic stem cell (HSC) niche maintenance. Recent advances in imaging and genetic manipulation of mouse models have allowed the identification of distinct vascular niches that have been shown to orchestrate the balance between quiescence, proliferation and regeneration of the bone marrow after injury. Here we highlight the recently discovered intrinsic mechanisms, microenvironmental interactions and communication with surrounding cells involved in HSC regulation, during homeostasis and in regeneration after injury and discuss their implications for regenerative therapy.

PMID:
25100529
[PubMed - indexed for MEDLINE]
PMCID:
PMC4459580
Free PMC Article
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