Gastroenterology. 1976 Feb;70(2):203-10.

Measurement of gastric functions during digestion of ordinary solid meals in man.

Malagelada JR, Longstreth GF, Summerskill WH, Go VL.

Abstract

A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quantifies emptying into the duodenum of another marker, [14C]PEG, incorporated in the meal. Acid and pepsin outputs can be determined without manipulation of the intragastric pH. Employing this method, we have simultaneously quantified acid, pepsin, and total secretory outputs; rates of gastric emptying of meal and secretions; and serum gastrin levels during digestion. These data characterize physiological responses to ordinary food in health.

PMID:: 2510; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Supplemental Content

Save items

Related citations in PubMed

Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals. [Dig Dis Sci. 1979]
Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals.
Malagelada JR, Go VL, Summerskill WH. Dig Dis Sci. 1979 Feb; 24(2):101-10.
Quantificantion of gastric solid-liquid discrimination during digestion of ordinary meals. [Gastroenterology. 1977]
Quantificantion of gastric solid-liquid discrimination during digestion of ordinary meals.
Malagelada JR. Gastroenterology. 1977 Jun; 72(6):1264-7.
Gastric secretion and emptying after ordinary meals in duodenal ulcer. [Gastroenterology. 1977]
Gastric secretion and emptying after ordinary meals in duodenal ulcer.
Malagelada JR, Longstreth GF, Deering TB, Summerskill WH, Go VL. Gastroenterology. 1977 Nov; 73(5):989-94.
Review Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori. [J Physiol Pharmacol. 1994]
Review Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Konturek JW. J Physiol Pharmacol. 1994 Dec; 45(4 Suppl 1):3-66.
Review [Problems of acid and enzyme substitution in stomach disorders]. [Dtsch Med Wochenschr. 1971]
Review [Problems of acid and enzyme substitution in stomach disorders].
Buchs S. Dtsch Med Wochenschr. 1971 Dec 3; 96(49):1925-9.

See reviews... See all...

Cited by 28 PubMed Central articles

Physiological Parameters for Oral Delivery and in Vitro Testing. [Mol Pharm. 2010]
Physiological Parameters for Oral Delivery and in Vitro Testing.
Mudie DM, Amidon GL, Amidon GE. Mol Pharm. 2010 Sep 7; . Epub 2010 Sep 7.
Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers. [World J Gastroenterol. 2008]
Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers.
Yamagishi H, Koike T, Ohara S, Horii T, Kikuchi R, Kobayashi S, Abe Y, Iijima K, Imatani A, Suzuki K, et al. World J Gastroenterol. 2008 Apr 7; 14(13):2049-54.
Hydrogen and oxygen isotope ratios in human hair are related to geography. [Proc Natl Acad Sci U S A. 2008]
Hydrogen and oxygen isotope ratios in human hair are related to geography.
Ehleringer JR, Bowen GJ, Chesson LA, West AG, Podlesak DW, Cerling TE. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2788-93. Epub 2008 Feb 25.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Measurement of gastric functions during digestion of ordinary solid meals in man...
Measurement of gastric functions during digestion of ordinary solid meals in man.
Gastroenterology. 1976 Feb ;70(2):203-10.

PubMed
Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila developmen...
Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.
Nature. 1989 Nov 9 ;342(6246):177-80.

PubMed
Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter...
Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group.
N Engl J Med. 1989 Nov 30 ;321(22):1501-6.

PubMed
Glaucoma in the Maroteaux-Lamy syndrome.
Glaucoma in the Maroteaux-Lamy syndrome.
Am J Ophthalmol. 1989 Oct 15 ;108(4):426-30.

PubMed
Preventive potential of antioxidative vitamins and carotenoids on cancer.
Preventive potential of antioxidative vitamins and carotenoids on cancer.
Int J Vitam Nutr Res Suppl. 1989 ;30:232-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Measurement of gastric functions during digestion of ordinary solid meals in man.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Supplemental Content

Save items

Related citations in PubMed

Cited by 28 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information