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Chemistry. 2014 Sep 15;20(38):12234-8. doi: 10.1002/chem.201403144. Epub 2014 Aug 5.

Copper-catalyzed aerobic oxidative inert C-C and C-N bond cleavage: a new strategy for the synthesis of tertiary amides.

Author information

  • 1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410081 (P. R. China), Fax: (+86) 731-88821171.

Abstract

A copper-catalyzed aerobic oxidative amidation reaction of inert C-C bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines C-C bond activation, C-N bond cleavage, and C-H bond oxygenation in a one-pot protocol, using molecular oxygen as the sole oxidant without any additional ligands.

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

CC activation; CN cleavage; aerobic oxidation; amidation; amides

PMID:
25099559
[PubMed - in process]
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