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Tumour Biol. 2014 Nov;35(11):11075-9. doi: 10.1007/s13277-014-2406-y. Epub 2014 Aug 6.

Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma.

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  • 1Department of Otorhinolaryngology, The Shengjing Hospital, China Medical University, Shenyang, 110004, Liaoning Province, China.

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs of endogenous origin that play an important role in tumor development. Here, we examined the role of miR-152 in supragalottic laryngeal carcinoma. The expression of miR-152 was assessed by real-time PCR in tissues from 83 patients with supragalottic laryngeal carcinoma in relation to clinicopathological parameters. Cell viability was assessed by thiazolyl blue assay in Hep-2 cells transfected with miR-152 mimics or a negative control. MiR-152 was significantly downregulated in supragalottic laryngeal carcinoma tissues (t = 12.65, p < 0.001, paired t test), and its expression was correlated with pT stage (χ (2) = 26.88, p < 0.001) and pN stage (z = -3.56, p < 0.001) in patients with supragalottic laryngeal carcinoma. MiR-152 inhibited the proliferation of Hep-2 cells. MiR-152 may serve as a novel prognostic marker in patients with supragalottic laryngeal carcinoma.

PMID:
25095980
[PubMed - in process]
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