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Mayo Clin Proc. 2014 Sep;89(9):1201-10. doi: 10.1016/j.mayocp.2014.05.014. Epub 2014 Aug 1.

Association between alcohol consumption and risk of cardiovascular disease and all-cause mortality in patients with hypertension: a meta-analysis of prospective cohort studies.

Author information

  • 1School of Public Health, Wuhan University, Wuhan, P. R. China.
  • 2School of Public Health, Wuhan University, Wuhan, P. R. China; Global Health Institute, Wuhan University, Wuhan, P. R. China.
  • 3School of Public Health, Wuhan University, Wuhan, P. R. China; Global Health Institute, Wuhan University, Wuhan, P. R. China. Electronic address: heqiqiang@gmail.com.

Abstract

OBJECTIVE:

To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations.

PATIENTS AND METHODS:

PubMed and EMBASE were searched for eligible prospective cohort studies from December 3, 1949, through January 18, 2014. The semi-parameter method and dose-response analysis were used.

RESULTS:

Nine studies (11 cohorts) were included in the meta-analysis. Compared with the lowest alcohol level (abstainers/occasional drinkers), the pooled relative risk (RR) was 0.72 (95% CI, 0.68-0.77) for the third highest category (median, 10 g/d), 0.81 (95% CI, 0.71-0.93) for the second highest category (median, 20 g/d), and 0.60 (95% CI, 0.54-0.67) for the highest category (median, 30 g/d). A J-shaped relationship between alcohol use and ACM was observed, and the nadir (RR, 0.82; 95% CI, 0.76-0.88) was found to be at a dose of 8 to 10 g of alcohol consumption per day.

CONCLUSION:

Findings of this meta-analysis suggest that low-to-moderate alcohol consumption was inversely significantly associated with the risk of CVD and ACM in patients with hypertension.

Copyright © 2014 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

PMID:
25091872
[PubMed - indexed for MEDLINE]
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