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Br J Oral Maxillofac Surg. 2014 Oct;52(8):715-20. doi: 10.1016/j.bjoms.2014.06.015. Epub 2014 Jul 30.

Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma.

Author information

  • 1Department of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming, China.
  • 2Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China; State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou, China.
  • 3Department of Radiotherapy, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming, China. Electronic address: wenhuili64@aliyun.com.
  • 4Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China; State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, Guangzhou, China. Electronic address: liql@sysucc.org.cn.

Abstract

We have investigated the clinical characteristics and prognostic factors of squamous cell carcinoma (SCC) of the tongue after definitive radiotherapy for nasopharyngeal carcinoma, and evaluated the effect of common therapeutic regimens for these patients. We retrospectively reviewed follow-up data for patients whose nasopharyngeal carcinoma had been treated by radiotherapy, and selected the 68 who had then developed SCC of the tongue, in the border of the tongue in half, and in the dorsum in 25 (37%). Eight of the 68 patients had clinical lymph node metastasis (12%), and 45 presented with stage I-II disease at the time of the diagnosis of the SCC (66%). Resection or radiotherapy alone was an effective treatment for patients with stage I-II SCC of the tongue, but patients with stage III-IV disease had a poor prognosis, despite being given multidisciplinary treatment. Multivariate analysis showed that the risk factors that independently influenced the survival of these patients were use of alcohol, recurrence of their nasopharyngeal carcinoma, the latency period, and the clinical TNM stage. Tongue SCC after radiotherapy was generally at an early stage and commonly occurred on the border or the dorsum of the tongue, with few lymph node metastases. Resection or radiotherapy is an effective treatment, and the risk factors that independently influenced the survival of patients indicate that improving the technique of radiotherapy and close follow-up after nasopharyngeal cancer are vitally important.

Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

KEYWORDS:

Latency period; Nasopharyngeal carcinoma; Radiotherapy; Second primary tumour; Tongue squamous cell carcinoma

PMID:
25085271
[PubMed - in process]
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