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PLoS One. 2014 Jul 31;9(7):e101524. doi: 10.1371/journal.pone.0101524. eCollection 2014.

Evaluating contextual processing in diffusion MRI: application to optic radiation reconstruction for epilepsy surgery.

Author information

  • 1Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Biomedical Engineering, Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • 2Department of Biomedical Engineering, Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands; Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • 3Department of Biomedical Engineering, Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands; Department of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands.
  • 4Department of Biomedical Engineering, Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • 5Department of Function and Medical Technology, Epilepsy Center Kempenhaeghe, Heeze, The Netherlands.
  • 6Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • 7Department of Biomedical Engineering, Biomedical Image Analysis, Eindhoven University of Technology, Eindhoven, The Netherlands; Department of Function and Medical Technology, Epilepsy Center Kempenhaeghe, Heeze, The Netherlands.

Abstract

Diffusion MRI and tractography allow for investigation of the architectural configuration of white matter in vivo, offering new avenues for applications like presurgical planning. Despite the promising outlook, there are many pitfalls that complicate its use for (clinical) application. Amongst these are inaccuracies in the geometry of the diffusion profiles on which tractography is based, and poor alignment with neighboring profiles. Recently developed contextual processing techniques, including enhancement and well-posed geometric sharpening, have shown to result in sharper and better aligned diffusion profiles. However, the research that has been conducted up to now is mainly of theoretical nature, and so far these techniques have only been evaluated by visual inspection of the diffusion profiles. In this work, the method is evaluated in a clinically relevant application: the reconstruction of the optic radiation for epilepsy surgery. For this evaluation we have developed a framework in which we incorporate a novel scoring procedure for individual pathways. We demonstrate that, using enhancement and sharpening, the extraction of an anatomically plausible reconstruction of the optic radiation from a large amount of probabilistic pathways is greatly improved in three healthy controls, where currently used methods fail to do so. Furthermore, challenging reconstructions of the optic radiation in three epilepsy surgery candidates with extensive brain lesions demonstrate that it is beneficial to integrate these methods in surgical planning.

PMID:
25077946
[PubMed - in process]
PMCID:
PMC4117467
Free PMC Article
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