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J La State Med Soc. 2014 Mar-Apr;166(2):78-80. Epub 2014 Apr 10.

Radiology case of the month: 49-year-old female with an anterior mediastinal mass.

Author information

  • 1Fourth-year Medical Student at Tulane University Health Sciences Center in New Orleans.
  • 2Pathology Resident at Tulane University Health Sciences Center.
  • 3Clinical Professor of Radiology at Tulane School of Medicine in New Orleans.
  • 4Professor of Radiology and Chairman of the Department of Radiology at Tulane School of Medicine in New Orleans.


Castleman's disease is an uncommon benign lymphoproliferative disorder characterized by hypervascular lymphoid hyperplasia. Two distinct histologic variants of Castleman's disease exist - hyaline vascular type and plasma cell type. The etiology is uncertain; however, it is thought to be inflammatory or hamartomatous in nature. Castleman's disease can occur at any age with a peak incidence in the third to fourth decade. This article presents a case of Castleman's disease in a female patient and aims to educate about the natural history, diagnosis, and management of the disease.

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