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Anticancer Res. 2014 Aug;34(8):4287-91.

Elderly woman with triple-negative metastatic breast cancer successfully treated with metronomic capecitabine.

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  • 1Department of Experimental Medicine, Sapienza University of Rome, Rome, Sapienza, Italy.
  • 2Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Sapienza University of Rome, Rome, Sapienza, Italy.
  • 3Department of Gynecology and Obstetrics, Sapienza University of Rome, Rome, Sapienza, Italy.
  • 4Department of Experimental Medicine, Sapienza University of Rome, Rome, Sapienza, Italy


Triple-negative breast cancer phenotype (estrogen receptor-, progesterone receptor- and human epidermal growth receptor 2-negative) is one of the most aggressive molecular subtypes, accounting for 15-20% of all breast tumors. There is no standard treatment for this setting of patients except anthracyclines and taxanes, but not all elderly patients can tolerate these kinds of agents. We describe the case of an elderly woman affected by triple-negative breast cancer with bone and brain metastases who has been treated for five years with metronomic capecitabine. At the moment, the patient has stable disease and enjoys good quality of life. She had initially been diagnosed with a poor Karnofsky index, which has actually improved from 50 to 90. Metronomic capecitabine treatment has clearly improved her quality of life, as documented by the results of the Functional Assessment of Cancer Therapy Breast.

Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.


FACT-B; T-negative breast cancer; bone metastasis; brain metastasis; capecitabine; metronomic chemotherapy; quality of life; stereotactic radiosurgery

[PubMed - indexed for MEDLINE]
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