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Chest. 1989 Oct;96(4):939-41.

Rapid resolution of acute cor pulmonale with recombinant tissue plasminogen activator.

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  • 1Department of Medicine, University of Massachusetts Medical School, Worcester.


A case of massive pulmonary embolism complicated by acute cor pulmonale and shock is presented. The IV administration of recombinant tissue-type plasminogen activator (rt-PA) was associated with prompt reversal of clinical, ECG, and nuclear radiographic findings. The role of thrombolytic therapy with rt-PA for massive pulmonary embolism associated with hemodynamic decompensation deserves further investigation.

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