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Biochem Biophys Res Commun. 2014 Sep 5;451(4):467-72. doi: 10.1016/j.bbrc.2014.07.041. Epub 2014 Jul 24.

Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats.

Author information

  • 1Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
  • 2Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.com.

Abstract

Changes of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression could impacts the viability of neurons and brain levels of brain-derived neurotrophic factor (BDNF) expression in the key brain structures in the pathophysiology of depressive disorder. In the present study, chronic unpredictable mild stress (CUMS) degraded performance decreased AMPA receptor expression and increased neuron apoptosis. Treatment with baicalin (20, 40mg/kg) significantly reversed these changes. This study demonstrates that baicalin has potent antidepressant effect, likely through up-regulated the expression of AMPA receptor and suppression neuron apoptosis in CUMS-treated rats.

Copyright © 2014. Published by Elsevier Inc.

KEYWORDS:

Antidepressant; Baicalin; Bax; Bcl-2; Caspase-3; GluR2 subunit

PMID:
25065744
[PubMed - indexed for MEDLINE]
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