Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Talanta. 2014 Oct;128:278-83. doi: 10.1016/j.talanta.2014.04.046. Epub 2014 May 14.

A polypyridyl-pyrene based off-on Cd²⁺ fluorescent sensor for aqueous phase analysis and living cell imaging.

Author information

  • 1Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China.
  • 2Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: wjruan@nankai.edu.cn.
  • 3Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: liyue84@nankai.edu.cn.
  • 4Department of Chemistry, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory on Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300071, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China. Electronic address: changze@nankai.edu.cn.

Abstract

By retaining the quadrapyridyl receptor of polypyridylhexaazatriphenylene (a Cd(2+) sensor reported by us) and extending its chromophoric group with pyrene, a chemical sensor (1) was designed and synthesized in this work. This sensor exhibit selective off-on fluorescence response to Cd(2+) over other metal ions, and the detection limit is as low as 0.02 μM. The Cd(2+) sensing of 1 has high water toleration and can be carried out in the media with the water content up to 70%. Additionally, 1 was successfully applied to the in vivo imaging of intracellular Cd(2+) in living HaLa cells, and showed low cytotoxicity and cell membrane permeability in these experiments. These results suggest that 1 has potential application in the Cd(2+) analysis of environmental and biological samples.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Cd2+ ion; Cell imaging; Fluorescent sensor; Quadrapyridyl type receptor; Water toleration

PMID:
25059161
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk