J Rheumatol. 1989 Jul;16(7):983-5.

Felty's syndrome: response to low dose oral methotrexate.

Isasi C, López-Martín JA, Angeles Trujillo M, Andreu JL, Palacio S, Mulero J.

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Servicio de Reumatología, Clínica Puerta de Hierro, Madrid, Spain.

Abstract

We describe a case of Felty's syndrome with persistent severe neutropenia below 200 granulocytes/mm3, splenomegaly and repeated infections. The patient did not respond to treatment with intramuscular gold salts and lithium carbonate. After 2 months of oral methotrexate administration, 7.5 mg weekly, clinical improvement was notable: she remained afebrile, neutropenia disappeared and splenomegaly regressed. This clinical and laboratory improvement persisted 5 months later. Moreover, accidental discontinuance of the drug and later readministration supported the evidence that the improvement was due to methotrexate.

Comment in

J Rheumatol. 1991 Mar;18(3):483-4.

PMID:: 2504919; [PubMed - indexed for MEDLINE]

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