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PLoS One. 2014 Jul 21;9(7):e98158. doi: 10.1371/journal.pone.0098158. eCollection 2014.

Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study.

Author information

  • 1Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
  • 2School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
  • 3Department and Graduate Institute of Health Care Management, Chang Gung University, Tao-Yuan, Taiwan.
  • 4Department of Nutrition and Health Sciences, Kainan University, Tao-Yuan, Taiwan.
  • 5Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Taipei, Taiwan; Division of Biostatistics, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan.



Previous studies on the association between tuberculosis and the risk of developing ischemic stroke have generated inconsistent results. We therefore performed a population-based, propensity score-matched longitudinal follow-up study to investigate whether contracting non-central nervous system (CNS) tuberculosis leads to an increased risk of ischemic stroke.


We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 5804 persons with at least three ambulatory visits in 2001 with the principal diagnosis of non-CNS tuberculosis were enrolled in the tuberculosis group. The non-tuberculosis group consisted of 5804, propensity score-matched subjects without tuberculosis. The three-year ischemic stroke-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. The stratified Cox proportional hazards regression was used to estimate the effect of tuberculosis on the occurrence of ischemic stroke.


During three-year follow-up, 176 subjects in the tuberculosis group (3.0%) and 207 in the non-tuberculosis group (3.6%) had ischemic stroke. The hazard ratio for developing ischemic stroke in the tuberculosis group was 0.92 compared to the non-tuberculosis group (95% confidence interval: 0.73-1.14, Pā€Š=ā€Š0.4299).


Non-CNS tuberculosis does not increase the risk of subsequent ischemic stroke.

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