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PLoS One. 2014 Jul 21;9(7):e98158. doi: 10.1371/journal.pone.0098158. eCollection 2014.

Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study.

Author information

  • 1Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
  • 2School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
  • 3Department and Graduate Institute of Health Care Management, Chang Gung University, Tao-Yuan, Taiwan.
  • 4Department of Nutrition and Health Sciences, Kainan University, Tao-Yuan, Taiwan.
  • 5Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Taipei, Taiwan; Division of Biostatistics, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan.

Abstract

BACKGROUND:

Previous studies on the association between tuberculosis and the risk of developing ischemic stroke have generated inconsistent results. We therefore performed a population-based, propensity score-matched longitudinal follow-up study to investigate whether contracting non-central nervous system (CNS) tuberculosis leads to an increased risk of ischemic stroke.

METHODS:

We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 5804 persons with at least three ambulatory visits in 2001 with the principal diagnosis of non-CNS tuberculosis were enrolled in the tuberculosis group. The non-tuberculosis group consisted of 5804, propensity score-matched subjects without tuberculosis. The three-year ischemic stroke-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. The stratified Cox proportional hazards regression was used to estimate the effect of tuberculosis on the occurrence of ischemic stroke.

RESULTS:

During three-year follow-up, 176 subjects in the tuberculosis group (3.0%) and 207 in the non-tuberculosis group (3.6%) had ischemic stroke. The hazard ratio for developing ischemic stroke in the tuberculosis group was 0.92 compared to the non-tuberculosis group (95% confidence interval: 0.73-1.14, Pā€Š=ā€Š0.4299).

CONCLUSIONS:

Non-CNS tuberculosis does not increase the risk of subsequent ischemic stroke.

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