Send to:

Choose Destination
See comment in PubMed Commons below
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug;118(2):236-40. doi: 10.1016/j.oooo.2014.04.006. Epub 2014 May 5.

Resorbable collagen membranes: histopathologic features.

Author information

  • 1Graduate student, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA. Electronic address:
  • 2Associate Professor, Boston University Henry Goldman School of Dental Medicine, Boston, MA, USA; Associate Pathologist, StrataDx Inc, Cambridge, MA, USA.
  • 3Associate Professor, Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, MA, USA; Associate Surgeon, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA; Co-director, Oral Pathology Center, StrataDx Inc, Cambridge, MA, USA.



Resorbable collagen membranes (RCMs) are commonly used by oral surgeons, periodontists, and endodontists for multiple purposes. We report 6 cases of RCMs that did not resorb as expected and describe the histopathologic features.


Cases of an unusual fibrillar foreign material were noted in biopsy specimens curetted from bone. Hematoxylin-eosin and Masson trichrome stains were performed. Clinicians were contacted for detailed clinical information.


There were 3 men and 3 women. RCMs presented as hyalinized, paucicellular, delicate eosinophilic fibrils or a meshwork without a foreign body reaction. They were refractile and stained for Masson trichrome as expected. These RCMs persisted longer than expected (2-6 weeks) in 3 cases and may have retarded healing in 5 cases.


Although RCM is supposed to be fairly rapidly resorbable, this material sometimes persists within wound sites without any obvious foreign body reaction and may retard healing.

Copyright © 2014 Elsevier Inc. All rights reserved.

[PubMed - in process]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk