Send to:

Choose Destination
See comment in PubMed Commons below
Bioanalysis. 2014 Jun;6(11):1543-61. doi: 10.4155/bio.14.102.

Bioanalysis of urine samples after manipulation by oxidizing chemicals: technical considerations.

Author information

  • 1Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, Ultimo, NSW 2007, Australia.


Drug testing programs are established to help achieve a drug-free work environment, promote fair competition in sport, facilitate harm minimization and rehabilitation programs, better manage patient care by clinicians and service law enforcement authorities. Urine remains the most popular and appropriate testing matrix for such purposes. However, urine is prone to adulteration, where chemicals, especially oxidizing chemicals, are purposely added to the collected urine specimens to produce a false-negative test result. This article will describe the effect of various popular oxidizing adulterants on urine drug test results, the countermeasures taken by laboratories in dealing with adulterated urine samples and the prospect of developing more robust and economical methods to combat urine adulteration in the future.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk