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Mech Ageing Dev. 2014 Sep;140:10-2. doi: 10.1016/j.mad.2014.07.001. Epub 2014 Jul 15.

Dietary advanced glycation end products are associated with decline in memory in young elderly.

Author information

  • 1The Icahn School of Medicine at Mount Sinai, New York, NY, US. Electronic address: rebecca.west@mssm.edu.
  • 2The Icahn School of Medicine at Mount Sinai, New York, NY, US.
  • 3The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.
  • 4The Icahn School of Medicine at Mount Sinai, New York, NY, US; The James J Peters Veterans Affairs Medical Center, Bronx, NY, US.
  • 5The Icahn School of Medicine at Mount Sinai, New York, NY, US; The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.

Abstract

We recently reported that serum methylglyoxal (sMG) is associated with a faster rate of decline in a global measure of cognition in the very elderly. We here provide for the first time evidence in which high levels of dietary AGE (dAGE) are associated with faster rate of decline in memory in 49 initially non-demented young elderly (p=0.012 in mixed regression models adjusting for sociodemographic and cardiovascular factors). Since modifying the levels of AGEs in the diet may be relatively easy, these preliminary results suggest a simple strategy to diminish cognitive compromise in the elderly and warrant further investigation.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Cognitive decline; Dietary advanced glycation end products; Memory; Methylglyoxal; Type 2 diabetes

PMID:
25037023
[PubMed - in process]
PMCID:
PMC4167353
[Available on 2015/9/1]
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