Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature

Mohammad Asl Zare; Mahmood Reza Kalantari; Amir Abbas Asadpour; Ali Kamalati

doi:10.5812/numonthly.15278

Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature

Nephrourol Mon. 2014 Apr 21;6(3):e15278. doi: 10.5812/numonthly.15278. eCollection 2014 May.

Authors

Mohammad Asl Zare¹, Mahmood Reza Kalantari², Amir Abbas Asadpour¹, Ali Kamalati³

Affiliations

¹ Department of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
² Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
³ Department of Urology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran.

Abstract

Introduction: Complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 XY karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives.

Case presentation: A 28-year-old woman with complete (severe) androgen resistance underwent prophylactic laparoscopic bilateral gonadectomy because of the eventually increased risk of gonadal malignancy. Although the gonads appeared grossly normal, microscopic examination revealed bilateral well differentiated sertoli-leydig cell tumor (SLCT).

Discussion: Our Medline search revealed that this is the first reported case of bilateral sertoli-leydig cell tumor (SLCT) in androgen insensitivity syndrome.

Keywords: Androgen-Insensitivity Syndrome; Laparoscopy; Sertoli-Leydig Cell Tumor.

Publication types

Case Reports