Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biomed Res Int. 2014;2014:474616. doi: 10.1155/2014/474616. Epub 2014 Jun 15.

Investigation of antiarthritic potential of Plumeria alba L. leaves in acute and chronic models of arthritis.

Author information

  • 1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India.
  • 2Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India ; Department of Pharmacy, School of Chemical Science and Pharmacy, Central University of Rajasthan, Ajmer 305801, India.
  • 3Dabur Research and Development Centre, Ghaziabad 201002, India.
  • 4All India Institute of Medical Sciences, New Delhi 110029, India.

Abstract

AIM:

The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of P. alba.

MATERIALS AND METHODS:

Plumeria alba L. leaves were extracted with hydroalcohol (30 : 70) to obtain hydroalcoholic extract of P. alba. This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively. These fractions were tested against formaldehyde and Freund's complete adjuvant (FCA) induced arthritis. Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured. On day 21, the animals were sacrificed and histopathology was done.

RESULTS:

The 100 and 200 mg/kg doses of EAPA and BPA caused a significant (P ≤ 0.05-0.01) reduction in paw swelling in both models. Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly (P < 0.01) in arthritic rats treated with extracts. There was significant (P < 0.05) improvement in thymus weight in EAPA treated rats whereas significant (P < 0.01) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group. Motor incoordination and nociceptive threshold were also significantly (P ≤ 0.05-0.01) improved.

CONCLUSION:

The present study suggests that Plumeria alba L. has protective activity against arthritis and supports the traditional use of P. alba for rheumatism and other inflammatory diseases.

PMID:
25025056
[PubMed - indexed for MEDLINE]
PMCID:
PMC4082847
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk