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World J Gastrointest Oncol. 2014 Jul 15;6(7):211-24. doi: 10.4251/wjgo.v6.i7.211.

Advances and new perspectives in the treatment of metastatic colon cancer.

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  • 1Gonzalo Recondo Jr, Enrique Díaz-Cantón, Máximo de la Vega, Martin Greco, Gonzalo Recondo Sr, Department of Medical Oncology, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires 1431, Argentina.


During the last decade we have witnessed an unprecedented outburst of new treatment approaches for the management of metastatic colon cancer. Anti-angiogenic drugs, epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes. However, this progress has paradoxically leaded us into new challenges. In many cases the clinical development was done in parallel and the lack of head-to-head comparison evolved into circumstances where several valid new "standards of care" are available. Even though desirable in essence, the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other, sometimes without solid evidence to support each decision. In addition, progress never stops and new agents are continuously tested. For these reason this review will try to summarize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature. Lastly, we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease.


Aflibercept; Bevacizumab; Cetuximab; Colon Cancer; Metastatic; Panitumumab; Regorafenib; Review; Stage IV

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