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Cross-reaction of immune sera from patients with rickettsial diseases.
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Rickettsia rickettsii and Rickettsia conorii are the causative agents of two common and serious diseases, Rocky Mountain spotted fever and Mediterranean spotted fever, respectively. In patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. The results of this study indicate that serodiagnostic tests with antigen from one of these two organisms could be used to detect antibodies in patients with either of the two rickettsial diseases.
PMID: 2501497 [PubMed - indexed for MEDLINE]
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Cited by 9 PubMed Central articles
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Differentiation of rickettsiae by groEL gene analysis.
Lee JH, Park HS, Jang WJ, Koh SE, Kim JM, Shim SK, Park MY, Kim YW, Kim BJ, Kook YH, et al.
J Clin Microbiol. 2003 Jul; 41(7):2952-60.
[J Clin Microbiol. 2003]
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Detection of Rickettsia prowazekii in body lice and their feces by using monoclonal antibodies.
Fang R, Houhamdi L, Raoult D.
J Clin Microbiol. 2002 Sep; 40(9):3358-63.
[J Clin Microbiol. 2002]
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Kinetics of antibody responses in Rickettsia africae and Rickettsia conorii infections.
Fournier PE, Jensenius M, Laferl H, Vene S, Raoult D.
Clin Diagn Lab Immunol. 2002 Mar; 9(2):324-8.
[Clin Diagn Lab Immunol. 2002]
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