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Drug Deliv. 2014 Jul 11:1-12. [Epub ahead of print]

Surfactant-based drug delivery systems for treating drug-resistant lung cancer.

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  • 1Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab , India.

Abstract

Abstract Among all cancers, lung cancer is the major cause of deaths. Lung cancer can be categorized into two classes for prognostic and treatment purposes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Both categories of cancer are resistant to certain drugs. Various mechanisms behind drug resistance are over-expression of superficial membrane proteins [glycoprotein (P-gp)], lung resistance-associated proteins, aberration of the intracellular enzyme system, enhancement of the cell repair system and deregulation of cell apoptosis. Structure-performance relationships and chemical compatibility are consequently major fundamentals in surfactant-based formulations, with the intention that a great deal investigation is committed to this region. With the purpose to understand the potential of P-gp in transportation of anti-tumor drugs to cancer cells with much effectiveness and specificity, several surfactant-based delivery systems have been developed which may include microspheres, nanosized drug carriers (nanoparticles, nanoemulsions, stealth liposomes, nanogels, polymer-drug conjugates), novel powders, hydrogels and mixed micellar systems intended for systemic and/or localized delivery.

KEYWORDS:

Drug resistance; glycoprotein; lung cancer; nanotechnological carriers; surfactants

PMID:
25013959
[PubMed - as supplied by publisher]
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