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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jun;39(6):552-7. doi: 10.11817/j.issn.1672-7347.2014.06.002.

[hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang].

[Article in Chinese]

Author information

  • 1Department of Blood, Enterology and Endocrinology, Chinese PLA 474 Hospital, Urumqi 830011,China.

Abstract

OBJECTIVE:

To explore the significance of hMSH2 aberrant expression in patients with sporadic colorectal cancer in Xinjiang Uygur Autonomous Region.

METHODS:

Clinicopathological parameters and postoperative samples of 327 patients with sporadic colorectal cancer were collected in Xinjiang Uygur Autonomous Region. Immunohistochemistry PV-9000 two-step method was performed to measure hMSH2 expression in the postoperative pathologic specimens. Prognostic value of hMSH2 expression was evaluated.

RESULTS:

Thirty-five (10.7%) patients showed aberrant nuclear staining of hMSH2 expression. The patients with aberrant expression of hMSH2 showed better prognosis than the normal expression group, with significant difference (P<0.05).

CONCLUSION:

In Xinjiang, aberrant hMSH2 expression can be regarded as an independent prognostic factor in patients with sporadic colorectal cancer.

PMID:
25011960
[PubMed - in process]
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