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Transplant Proc. 2014 Sep;46(7):2373-6. doi: 10.1016/j.transproceed.2014.02.014. Epub 2014 Jul 8.

Long-term complete remission of multiple extranodal natural killer/T-cell-type posttransplant lymphoproliferative disorder after surgical resection: a case report.

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  • 1Division of Surgery, Hachinohe City Hospital, Japan. Electronic address:
  • 2Division of Surgery, Hachinohe City Hospital, Japan.
  • 3Division of Pathology, Hachinohe City Hospital, Japan.
  • 4Division of Pathology, Hakodate Municipal Hospital, Japan.
  • 5Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Miyagi, Japan.



Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of organ transplantation that results from immunosuppression therapy. Most cases of PTLD derive from the B-cell lineage. T-cell PTLD, particularly natural killer (NK)/T-cell PTLD, is quite rare; only a few cases have been described.


A 42-year-old woman received a living-related renal allograft from her father. Sixteen years after transplantation, the patient presented with a 1-week history of low-grade fever and epigastralgia. Computed tomography revealed intestinal masses and a right upper lung lobe mass. Gallium scintigraphy showed uptake in the abdominal mass. Epstein-Barr virus-related antibody was not detected in the patient's serum sample. We performed extirpation of the jejunum and ileum tumors. The pathologic findings showed that these 2 tumors were NK/T-cell lymphoma. After the operation, the lung mass rapidly enlarged, and right upper lobectomy was performed. The right upper lung lobe tumor showed the same histopathologic findings as the small bowel tumor. The final histologic diagnosis was established as multiple extranodal NK/T cell type PTLD of the small bowel and right upper lung lobe.


After reduction of the immunosuppressive agent, no recurrence of PTLD has been observed for the past 9 years.

Copyright © 2014 Elsevier Inc. All rights reserved.

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