Send to:

Choose Destination
See comment in PubMed Commons below
Maturitas. 2014 Sep;79(1):70-6. doi: 10.1016/j.maturitas.2014.06.006. Epub 2014 Jun 16.

Combined conjugated esterified estrogen plus methyltestosterone supplementation and risk of breast cancer in postmenopausal women.

Author information

  • 1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address:
  • 2Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States.
  • 3Department of Medicine, Arizona Cancer Center, Tucson, AZ, United States.
  • 4Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  • 5Department of Preventive Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, United States.
  • 6Departments of Epidemiology and Medicine, Brown University, Providence, RI, United States.
  • 7Department of Public Health Sciences, School of Medicine, University of California at Davis, Davis, CA, United States.
  • 8Karmanos Cancer Institute, Detroit, MI, United States.
  • 9Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States.



Testosterone supplementation is being prescribed increasingly to treat symptoms of hormone deficiency in pre- and postmenopausal women; however, studies of the association of testosterone therapy, alone or in combination with estrogen, with risk of breast cancer are limited. The current study assessed the association of combination conjugated esterified estrogen and methyltestosterone (CEE+MT) use and breast cancer risk in postmenopausal women in the Women's Health Initiative (WHI).


At Year 3 of follow-up, women in the WHI observational study (N=71,964) provided information on CEE+MT use in the past two years, duration of use, and the brand name of the product. In addition, in each of years 4-8, women were asked whether they had used CEE+MT in the previous year. After 10 years of follow-up, 2832 incident breast cancer cases were identified. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for the association of CEE+MT use (irrespective of use of other hormones) and of exclusive CEE+MT use in relation to breast cancer risk.


Neither CEE+MT use nor exclusive use of CEE+MT was associated with risk: multivariable-adjusted HR 1.06, 95% CI 0.82-1.36 and HR 1.22, 95% CI 0.78-1.92, respectively. Among women with a natural menopause, the HR for exclusive use was 1.32 (95% CI 0.68-2.55). There was no indication of an association when repeated measures of CEE+MT use were included in a time-dependent covariates analysis.


The present study, the largest prospective study to date, did not show a significant association of CEE+MT supplementation and risk of breast cancer.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.


Androgens; Breast cancer; Conjugated esterified estrogen plus methyltestosterone supplementation; Postmenopausal women

[PubMed - in process]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk