Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA Ophthalmol. 2014 Oct;132(10):1226-31. doi: 10.1001/jamaophthalmol.2014.1752.

The relationship between hepatic lipase gene variant and advanced age-related macular degeneration: a meta-analysis.

Author information

  • 1Department of Ophthalmology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.
  • 2Department of Oncology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China.

Abstract

IMPORTANCE:

To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).

OBJECTIVE:

To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.

DATA SOURCES:

The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013.

STUDY SELECTION:

Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy).

DATA EXTRACTION AND SYNTHESIS:

Allele frequencies and genotype distributions of rs10468017 variant.

MAIN OUTCOMES AND MEASURES:

Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis.

RESULTS:

Data from 10 case-control studies were included in the meta-analysis. The rs10468017 variant (C→T) showed significant summary ORs of 0.81 (95% CI, 0.75-0.88), 0.83 (95% CI, 0.70-0.98), and 0.60 (95% CI, 0.44-0.81) under the allelic (T vs C), heterozygous (TC vs CC), and homozygous (TT vs CC) models, respectively. Carrying at least 1 copy of the T allele decreased the risk of choroidal neovascularization and geographic atrophy by 20% (OR, 0.80; 95% CI, 0.74-0.87) and 29% (OR, 0.71; 95% CI, 0.59-0.86), respectively. The pooled OR for white race/ethnicity under an allelic model was 0.80 (95% CI, 0.74-0.87). The sensitivity analysis indicated the robustness of our findings, and no evidence of publication bias was observed in our meta-analysis.

CONCLUSIONS AND RELEVANCE:

Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. This finding may lead to insights regarding the pathogenesis, prevention, and treatment of AMD.

PMID:
25010633
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk