Abstract
The output of prostaglandins I2, E2, F2 alpha and 13,14-dihydro-15-keto-PGF2 alpha (PGFM) from third passage day 20 rat fetal fibroblasts and type II alveolar pneumonocytes was studied. In 2 h incubations, the output levels for each cell type were: PGI2 greater than PGE2 much greater than PGF2 alpha = PGFM when cells were incubated with Ca2+ ionophore A23187 (10 microM) or arachidonic acid (1 microgram/ml).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arachidonic Acid
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Arachidonic Acids / pharmacology
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Calcimycin / pharmacology
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Cells, Cultured
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Dinoprostone / biosynthesis
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Epoprostenol / biosynthesis
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Fibroblasts / metabolism
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In Vitro Techniques
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Lung / embryology
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Lung / metabolism*
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Prostaglandins / biosynthesis*
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Rats
Substances
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Arachidonic Acids
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Prostaglandins
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Arachidonic Acid
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Calcimycin
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Epoprostenol
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Dinoprostone