Production of prostaglandins by fetal rat lung type II pneumonocytes and fibroblasts

Biochim Biophys Acta. 1989 Jun 28;1003(3):327-30. doi: 10.1016/0005-2760(89)90240-3.

Abstract

The output of prostaglandins I2, E2, F2 alpha and 13,14-dihydro-15-keto-PGF2 alpha (PGFM) from third passage day 20 rat fetal fibroblasts and type II alveolar pneumonocytes was studied. In 2 h incubations, the output levels for each cell type were: PGI2 greater than PGE2 much greater than PGF2 alpha = PGFM when cells were incubated with Ca2+ ionophore A23187 (10 microM) or arachidonic acid (1 microgram/ml).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / pharmacology
  • Calcimycin / pharmacology
  • Cells, Cultured
  • Dinoprostone / biosynthesis
  • Epoprostenol / biosynthesis
  • Fibroblasts / metabolism
  • In Vitro Techniques
  • Lung / embryology
  • Lung / metabolism*
  • Prostaglandins / biosynthesis*
  • Rats

Substances

  • Arachidonic Acids
  • Prostaglandins
  • Arachidonic Acid
  • Calcimycin
  • Epoprostenol
  • Dinoprostone