Send to:

Choose Destination
See comment in PubMed Commons below
Seizure. 2014 Oct;23(9):762-8. doi: 10.1016/j.seizure.2014.06.007. Epub 2014 Jun 26.

Predictors of quality of life and their interrelations in Korean people with epilepsy: a MEPSY study.

Author information

  • 1Department of Neurology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
  • 2Department of Neurology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
  • 3Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • 4Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
  • 5Department of Neurology, Daegu Fatima Hospital, Republic of Korea.
  • 6Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:



People with epilepsy (PWE) are more likely to have impaired quality of life (QOL) than the general population. We studied predictors of QOL and their interrelations in Korean PWE.


Subjects who consecutively visited outpatient clinics in four tertiary hospitals and one secondary care hospital were enrolled. These subjects completed the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Generalized Anxiety Disorder-7 (GAD-7), the Quality of Life in Epilepsy-10 (QOLIE-10), and the Korean version of Liverpool Adverse Event Profile (K-LAEP). We evaluated the predictors of QOL by multiple regression analyses and verified the interrelations between the variables using a structural equation model.


A total of 702 PWE were eligible for the study. The strongest predictor of the overall QOLIE-10 score was the K-LAEP score (β=-0.375, p<0.001), followed by the K-NDDI-E score (β=-0.316, p<0.001), seizure control (β=-0.152, p<0.001), household income (β=-0.375, p<0.001), and GAD-7 score (β=-0.119, p=0.005). These variables explained 68.7% of the variance in the overall QOLIE-31 score. Depression and seizure control had a bidirectional relationship and exerted direct effects on QOL. These factors also exerted indirect effects on QOL by provoking adverse effects of AEDs. Anxiety did not have a direct effect on QOL; it had only indirect effect through the adverse effects of AEDs.


Depression, anxiety, seizure control, and adverse effects of AEDs have complex interrelations that determine the QOL of PWE.

Copyright © 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.


Adverse effect; Depression; Epilepsy; Predictor; Quality of life; Seizure control

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk