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Curr Med Res Opin. 2014 Oct;30(10):1971-4. doi: 10.1185/03007995.2014.941978. Epub 2014 Jul 15.

Achieving lipid targets in primary care settings.

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  • 12nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital , Thessaloniki , Greece.


Achieving low-density lipoprotein cholesterol (LDL-C) goals in clinical practice is still unsatisfactory. Furthermore, a significant residual risk remains, even after reaching LDL-C targets, in terms of both fasting and postprandial triglycerides, high-density lipoprotein cholesterol (quantity and quality) and small dense LDL particles. Statins are the first choice for treating lipid abnormalities. Other lipid-lowering agents can be administered when statins are not tolerated and if LDL-C targets are not reached. Furthermore, multifactorial treatment, including a statin, exerts several beneficial effects on cardiovascular and residual risk reduction. The role of novel developing lipid therapies in clinical practice remains to be established.


High-density lipoprotein cholesterol; Low-density lipoprotein cholesterol; Multifactorial treatment; Small dense low-density lipoprotein cholesterol; Statins; Triglycerides

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