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J Invest Dermatol. 2015 Jan;135(1):258-68. doi: 10.1038/jid.2014.288. Epub 2014 Jul 9.

Galectin-1 accelerates wound healing by regulating the neuropilin-1/Smad3/NOX4 pathway and ROS production in myofibroblasts.

Author information

  • 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • 2Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • 3Institute for Translational Medicine, Taipei Medical University, Taipei, Taiwan.
  • 4Department of Internal Medicine, Division of Hematology and Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 51] Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan [2] Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • 61] Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan [2] Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Abstract

Myofibroblasts have a key role in wound healing by secreting growth factors and chemoattractants to create new substrates and proteins in the extracellular matrix. We have found that galectin-1, a β-galactose-binding lectin involved in many physiological functions, induces myofibroblast activation; however, the mechanism remains unclear. Here, we reveal that galectin-1-null (Lgals1(-/-)) mice exhibited a delayed cutaneous wound healing response. Galectin-1 induced myofibroblast activation, migration, and proliferation by triggering intracellular reactive oxygen species (ROS) production. A ROS-producing protein, NADPH oxidase 4 (NOX4), was upregulated by galectin-1 through the neuropilin-1/Smad3 signaling pathway in myofibroblasts. Subcutaneous injection of galectin-1 into wound areas accelerated the healing of general and pathological (streptozotocin-induced diabetes mellitus) wounds and decreased the mortality of diabetic mice with skin wounds. These findings indicate that galectin-1 is a key regulator of wound repair that has therapeutic potential for pathological or imperfect wound healing.

PMID:
25007042
[PubMed - indexed for MEDLINE]
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