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Curr Top Microbiol Immunol. 2014;380:191-212. doi: 10.1007/978-3-662-43492-5_9.

The molecular basis of IL-10 function: from receptor structure to the onset of signaling.

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  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA,


Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.

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