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J Clin Psychiatry. 1990 Sep;51(9):388-9.
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J Clin Psychiatry. 1993 May;54(5):202.
Seizures and bupropion: a review.
Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710.
The relationship between seizure occurrence and use of bupropion was examined on the basis of manufacturer's reports. The observed incidence of seizures with bupropion doses of 450 mg/day or less ranged from 0.35%-0.44%, depending on the method of calculation. The cumulative 2-year risk of seizures in patients receiving the maximum recommended dose of 450 mg/day or less was 0.48%. The risk of seizure appears to be higher with bupropion doses above the recommended maximum, and predisposing factors were noted in over half of the 37 reported cases. Possible risk factors are presented and recommendations are given for the use of bupropion.
PMID: 2500425 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents.
Henshall DC, Dürmüller N, White HS, Williams R, Moser P, Dunleavy M, Silverstone PH.
Neuropsychiatr Dis Treat. 2009; 5:189-206. Epub 2009 Apr 8.
[Neuropsychiatr Dis Treat. 2009]
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Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice.
Silverstone PH, Williams R, McMahon L, Fleming R, Fogarty S.
Ann Gen Psychiatry. 2008 Dec 23; 7:27. Epub 2008 Dec 23.
[Ann Gen Psychiatry. 2008]
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Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice.
Silverstone PH, Williams R, McMahon L, Fleming R, Fogarty S.
Ann Gen Psychiatry. 2008 Oct 15; 7:19. Epub 2008 Oct 15.
[Ann Gen Psychiatry. 2008]
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