Send to:

Choose Destination
See comment in PubMed Commons below
Acta Psychiatr Scand. 1989 Apr;79(4):378-85.

Adding lithium carbonate to carbamazepine: antimanic efficacy in treatment-resistant mania.

Author information

  • 1Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland.


Although lithium and carbamazepine used alone are effective in treating acute mania, some patients do not respond adequately to either of these medications used alone. We assessed, under double-blind conditions, a potential synergism between carbamazepine and lithium in the acute treatment of mania. Six of 7 manic patients who had previously been largely refractory to lithium alone, and who still showed substantial mania after several weeks of double-blind treatment with carbamazepine, improved following the blind addition of lithium. The clinical and theoretical implications of the response to this combination treatment are discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk